Editorial Type:
Article Category: Research Article
| Online Publication Date: 01 Aug 2000
Characterization of Adhesive and Neurotoxic Components in Skin Granular Gland Secretions of Ambystoma tigrinum
Characterization of Adhesive and Neurotoxic Components in Skin Granular Gland Secretions of Ambystoma tigrinum
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Page Range: 856 – 859
Ambystomatid salamanders have been shown to have toxic and adhesive secretions which serve as important antipredator mechanisms. Here we show that at least one component in Ambystoma tigrinum secretion inhibits neurotransmission in slices of rat hippocampus. Further, we show that disulfide linkages in proteins are necessary for the adhesive properties of the secretion.Abstract
Copyright: The American Society of Ichthyologists and Herpetologists
Fig. 1.
Inhibition of the orthodromic response in Shaffer Collateral-CA1 pathway. (A) Response before the addition of secretion. (B) Same response 4 min after the addition of 80 µl of secretion
Fig. 2.
Inhibition of the antidromic response in CA1 neurons. (A) Response before the addition of secretion. (B) Same response 4 min after the addition of 90 µl of secretion
Accepted: 14 Feb 2000